Normal Prion Function

Normal Prion Function

Our knoledge about the normal prion protein is indeed not very good. Roland Heynkes has graciously provided the list of references that deal with the normal prion protein function.

Roland Heynkes
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D-52072 Aachen (Germany)
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Literature List:

Atouf,F.; Scharfmann,R.; Lasmezas,C.; Czernichow,P.
Tight hormonal control of PrP gene expression in endocrine pancreatic cells
Biochemical and Biophysical Research Communications 1994 Jun 30; 201(3): 1220-6 Bendheim,P.E.; Brown,H.R.; Rudelli,R.D.; Scala,L.J.; Goller,N.L.; Wen,G.Y.; Kascsak,R.J.; Cashman,N.R.; Bolton,D.C.
Nearly ubiquitous tissue distribution of the scrapie agent precursor protein
Neurology 1992 Jan; 42(1): 149-56 Borchelt,D.R.; Koliatsos,V.E.; Guarnieri,M.; Pardo,C.A.; Sisodia,S.S.; Price,D.L.
Rapid anterograde axonal transport of the cellular prion glycoprotein in the peripheral and central nervous systems - The Journal of Biological Chemistry 1994 May 20; 269(20): 14711-4 Borchelt,D.R.; Rogers,M.; Stahl,N.; Telling,G.; Prusiner,S.B. - Release of the cellular prion protein from cultured cells after loss of its glycoinositol phospholipid anchor
Glycobiology 1993 Aug; 3(4): 319-29 Borchelt,D.R.; Scott,M.; Taraboulos,A.; Stahl,N.; Prusiner,S.B. - Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells
The Journal of Cell Biology 1990 Mar; 110(3): 743-52 Brown,H.R.; Goller,N.L.; Rudelli,R.D.; Merz,G.S.; Wolfe,G.C.; Wisniewski,H.M.; Robakis,N.K.
The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells
Acta neuropathologica 1990; 80(1): 1-6 BTeler,H.; Fischer,M.; Lang,Y.; Bluethmann,H.; Lipp,H.P.; DeArmond,S.J.; Prusiner,S.B.; Aguet,M.; Weissmann,C.
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein [see comments]
Nature 1992 Apr 16; 356(6370): 577-82 Castelnau,P.; Lazarini,F.; Deslys,J.P.; Dormont,D.
Prion protein gene expression in cultured astrocytes treated by recombinant growth hormone and insulin-like growth factor
Experimental Neurology 1994 Dec; 130(2): 407-10 Collinge,J.; Whittington,M.A.; Sidle,K.C.L.; Smith,C.J.; Palmer,M.S.; Clarke,A.R.; Jefferys,J.G.R.
Prion protein is necessary for normal synaptic function - Nature 1994 Jul 28; 370(6487): 295-7 Denman,R.; Potempska,A.; Wolfe,G.; Ramakrishna,N.; Miller,D.L.
Distribution and activity of alternatively spliced Alzheimer amyloid peptide precursor and scrapie PrP mRNAs on rat brain polysomes
Archives of Biochemistry and Biophysics 1991 Jul; 288(1): 29-38 Forloni,G.; Angeretti,N.; Chiesa,R.; Monzani,E.; Salmona,M.; Bugiani,O.; Tagliavini,F.
Neurotoxicity of a prion protein fragment - Nature 1993 Apr 8; 362(6420): 543-6 Fournier,J.G.; Escaighaye,F.; Devillemeur,T.B.; Robain,O.
Ultrastructural localization of cellular prion protein (PrPc) in synaptic boutons of normal hamster hippocampus - Comptes Rendus de l'Academie des Sciences Serie III
Sciences de la Vie 1995 Mar; 318(3): 339-44 Gabriel,J.M.; Oesch,B.; Kretzschmar,H.; Scott,M.; Prusiner,S.B.
Molecular cloning of a candidate chicken prion protein - Proceedings of the National Academy of Sciences of the United States of America 1992 Oct 1; 89(19): 9097-101 Halabi,G.; Morelon,E.; Lavery,P.; Loertscher,R.
Beta(2) microglobulin (beta(2)m) supports the transport of the cellular prion glycoprotein (prpc) to the cell-surface
Kidney International 1995; 48(N1): 298 Harmey,J.H.; Doyle,D.; Brown,V.; Rogers,M.S.
The cellular isoform of the prion protein, PrP(C), is associated with caveolae in mouse neuroblastoma (N(2)a) cells
Biochemical and Biophysical Research Communications 1995 May 25; 210(3): 753-9 Harris,D.A.; Lele,P.; Snider,W.D.
Localization of the mRNA for a chicken prion protein by in situ hybridization
Proceedings of the National Academy of Sciences of the United States of America 1993 May 1; 90(9): 4309-13 Harris,D.A.; Huber,M.T.; van-Dijken,P.; Shyng,S.L.; Chait,B.T.; Wang,R.
Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites. - Biochemistry 1993 Feb 2; 32(4): 1009-16 Harris,D.A.; Falls,D.L.; Johnson,F.A.; Fischbach,G.D.
A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity
Proceedings of the National Academy of Sciences of the United States of America 1991 Sep 1; 88(17): 7664-8 Horiuchi,M.; Yamazaki,N.; Ikeda,T.; Ishiguro,N.; Shinagawa,M.
A cellular form of prion protein (PrPC) exists in many non- neuronal tissues of sheep
Journal of General Virology 1995 Oct; 76(Part 10): 2583-7 Hornshaw,M.P.; McDermott,J.R.; Candy,J.M.
Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein - Biochemical and Biophysical Research Communications 1995 Feb 15; 207(2): 621-9 Huang,Z.W.; Cohen,F.E.; Prusiner,S.B.
Structural basis of prion diseases
Journal of Cellular Biochemistry 1995; 1995(S21B): 103 Huang,Z.W.; Gabriel,J.M.; Baldwin,M.A.; Fletterick,R.J.; Prusiner,S.B.; Cohen,F.E.
Proposed three-dimensional structure for the cellular prion protein
Proceedings of the National Academy of Sciences of the United States of America 1994 Jul 19; 91(15): 7139-43 Kretzschmar,H.A.; Prusiner,S.B.; Stowring,L.E.; DeArmond,S.J.
Scrapie prion proteins are synthesized in neurons
American Journal of Pathology 1986 Jan; 122(1): 1-5 Kurschner,C.; Morgan,J.I.
Analysis of interaction sites in homomeric and heteromeric complexes containing bcl-2 family members and the cellular prion protein
Molecular Brain Research 1996; 37(N1-2): 249-58 Kurschner,C.; Morgan,J.I.
The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system
Molecular Brain Research 1995 May; 30(1): 165-8 Lazarini,F.; Castelnau,P.; Chermann,J.F.; Deslys,J.P.; Dormont,D.
Modulation of Prion Protein Gene Expression by Growth Factors in Cultured Mouse Astrocytes and PC-12 Cells
Molecular Brain Research 1994 Mar; 22(1-4): 268-74 Loertscher,R.; Lavery,P.; White,M.; Lazarovits,A.I.
Cellular prion protein (prpc) clusters with beta(2) microglobulin (beta(2)m) on the cell-surface of human- lymphocytes
Kidney International 1995; 48(N1): 298 Manson,J.C.; Clarke,A.R.; Hooper,M.L.; Aitchison,L.; McConnell,I.; Hope,J.
129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal - Molecular Neurobiology 1994 Apr-Jun; 8(2-3): 121-127 Manson,J.C.; West,J.D.; Thomson,V.; McBride,P.; Kaufman,M.H.; Hope,J.
The prion protein gene: a role in mouse embryogenesis?
Development 1992 May; 115(1): 117-22 McBride,P.A.; Eikelenboom,P.; Kraal,G.; Fraser,H.; Bruce,M.E.
PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice
Journal of Pathology 1992 Dec; 168(4): 413-8 Moser,M.; Colello,R.J.; Pott,U.; Oesch,B.
Developmental expression of the prion protein gene in glial cells
Neuron 1995 Mar; 14(3): 509-17 Nakahara,D.H.; Lingappa,V.R.; Chuck,S.L.
Translocational pausing is a common step in the biogenesis of unconventional integral membrane and secretory proteins
The Journal of Biological Chemistry 1994 Mar 11; 269(10): 7617-22 Oesch,B.; Moser,M.; Coufal,F.; Prusiner,S.B.; DeArmond,S.J.
Distribution of the prion protein and its ligands - implications for spongiform encephalopathies
Journal of Cellular Biochemistry 1995; 1995(S21B): 106 Shyng,S.L.; Moulder,K.L.; Lesko,A.; Harris,D.A.
The n-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits
The Journal of Biological Chemistry 1995 Jun 1; 270(24): 14793-800 Stahl,N.; Baldwin,M.A.; Hecker,R.; Pan,K.M.; Burlingame,A.L.; Prusiner,S.B.
Glycosylinositol phospholipid anchors of the scrapie and cellular prion proteins contain sialic acid
Biochemistry 1992 Jun 2; 31(21): 5043-53 Taraboulos,A.; Scott,M.; Semenov,A.; Avraham,D.; Laszlo,L.; Prusiner,S.B.
Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform
The Journal of Cell Biology 1995 Apr; 129(1): 121-32 Toh,B.H.; Gibbs,C.J. Jr; Gajdusek,D.C.; Tuthill,D.D.; Dahl,D.
The 200- and 150-kDa neurofilament proteins react with IgG autoantibodies from chimpanzees with kuru or Creutzfeldt-Jakob disease; a 62-kDa neurofilament-associated protein reacts with sera from sheep with natural scrapie.
Proceedings of the National Academy of Sciences of the United States of America 1985 Jun; 82(11): 3894-6 Whatley,S.A.; Powell,J.F.; Politopoulou,G.; Campbell,I.C.; Brammer,M.J.; Percy,N.S.
Regulation of intracellular free calcium levels by the cellular prion protein
Neuroreport 1995; 6(N17): 2333-7 Whittington,M.A.; Sidle,K.C.L.; Gowland,I.; Meads,J.; Hill,A.F.; Palmer,M.S.; Jefferys,J.G.R.; Collinge,J.
Rescue of neurophysiological phenotype seen in prp null mice by transgene encoding human prion protein - Nature Genetics 1995 Feb; 9(2): 197-201